منابع مشابه
ubiquitin-mediated proteolysis after release from telomeres
Mammalian telomeres are coated by the sequence-specific, DNA-binding protein, TRF1, a negative regulator of telomere length. Previous results showed that ADP-ribosylation of TRF1 by tankyrase 1 released TRF1 from telomeres and promoted telomere elongation. We now show that loss of TRF1 from telomeres results in ubiquitination and degradation of TRF1 by the proteasome and that degradation is req...
متن کاملProteolysis and the biochemistry of life-or-death decisions
A Poptosis, the process by which cells commit suicide, is ubiquitous in both normal and diseased tissues, and its mechanism is conserved in animal species from humans at least to nematodes. Apoptotic cells undergo a stereotypical set of changes--shrinkage, cleavage of nuclear DNA, condensation of chromatin, fragmentation of the cytoplasm-that distinguish them from cells dying by other means. In...
متن کاملIncreased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis.
Rat gastrocnemius showed increased protein degradation (+75-115%) at 48 h after traumatic injury. Injured muscle showed increased cathepsin B activity (+327%) and mRNA encoding cathepsin B (+670%), cathepsin L (+298%), cathepsin H (+159%), and cathepsin C (+268%). In in situ hybridization, cathepsin B mRNA localized to the mononuclear cell infiltrate in injured muscle, and only background level...
متن کاملLife and destruction: ubiquitin-mediated proteolysis in aging and longevity
The ubiquitin/proteasome system (UPS) regulates the turnover of improperly folded and damaged proteins to maintain protein homeostasis (proteostasis), cellular function, and viability. It is commonly thought that an age-related impairment of the UPS affects general proteostasis networks, which causes enhanced protein aggregation and contributes to normal aging. Recent studies identified the exi...
متن کاملLife after stoma creation.
BACKGROUND Stoma creation is a surgical operation where the surgeon makes an artificial opening on the abdomen from where the bowel is taken out. It is a radical treatment with permanent physical signs of bodily change. In general, it leads to loss of a central and personal physical function, as well as an alteration in the bodily design. Research in the field may provide additional information...
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2009
ISSN: 1942-0889
DOI: 10.4161/cib.7700